Kenneth D. Philipson, Ph.D.
Curriculum Vitae
 

Education

1968

B.S. in Chemistry
University of Chicago

1972

Ph.D. in Chemistry
University of California, Berkeley

Positions

2000-

Chairman, Department of Physiology
UCLA School of Medicine

1997-

Associate Director, Cardiovascular Research Laboratory
UCLA School of Medicine

1995-2000

Vice Chair, Department of Physiology
UCLA School of Medicine

1987-

Professor, Depts of Physiology and Medicine
UCLA School of Medicine

1983-1987

Associate Professor, Depts of Medicine and Physiology
UCLA School of Medicine

1985

Guest Professor, Laboratory for Biochemistry
Swiss Federal Institute of Technology, Zurich

1980-1983

Assistant Professor, Depts of Medicine and Physiology
UCLA School of Medicine

1976-1980

Assistant Research Physiologist, Cardiovascular Research Laboratory
UCLA School of Medicine

1973-1976

Research Fellow, Cardiovascular Research Institute
University of California, San Francisco, School of Medicine

Honors

1992-2002

NIH MERIT Award

1995

AHA-GLAA Distinguished Scientific Achievement in Cardiovascular Research Award

1993

Distinguished Scientist Lecturer, Loyola University, School of Medicine, Chicago

1992

Distinguished Scientist Lecturer, University of South Alabama School of Medicine, Mobile

1992

Keynote Speaker, AHA California Affiliate Conference, Asilomar

1990

Graduate Student Lecturer, Department of Physiology, University of Texas Southwestern Medical Center, Dallas

1983-1988

Established Investigatorship of the American Heart Association

Selected Publications

1. Tsuruya, Y., Bersohn, M.M., Li, Z., Nicoll, D.A. and Philipson, K.D. Molecular cloning and functional expression of the guinea pig cardiac Na⁺-Ca²⁺ exchanger. Biochim. Biophys. Acta., 1196:97-99, 1995.

2. Chen, F., Mottino, G., Klitzner, T.S., Philipson, K.D. and Frank, J.S. Distribution of the Na⁺-Ca²⁺ exchange protein in developing rabbit myocytes. Am. J. Physiol., 268:C1126-C1132, 1995.

3. Matsuoka, S., Nicoll, D.A., Hryshko, L.V., Levitsky, D.O., Weiss, J.N. and Philipson, K.D. Regulation of the cardiac Na⁺-Ca²⁺ exchanger by Ca²⁺: Mutational analysis of the Ca²⁺ binding domain. J. Gen. Physiol., 105:403-420, 1995.

4. Sahin-Toth, M., Nicoll, D.A., Frank, J.S., Philipson, K.D. and Friedlander, M. The cleaved N-terminal signal sequence of the cardiac Na⁺-Ca²⁺ exchanger is not required for functional membrane integration. Biochem. Biophys. Res. Comm. 212:968-974, 1995.

5. Nicoll, D.A., Hyrshko, L.V., Matsuoka, S., Frank, J.S. and Philipson, K.D. Mutation of amino acid residues in the putative transmembrane segments of the cardiac sarcolemma Na⁺-Ca²⁺ exchanger. J. Biol. Chem. 271:13385-13391, 1996.

6. Hryshko, L.V., Matsuoka, S., Nicoll, D.A., Weiss, J.N., Schwarz, E.M., Benzer, S. and Philipson, K.D. Anomalous regulation of the Drosophila Na⁺-Ca²⁺ exchanger by Ca²⁺. J. Gen. Physiol. 108:67-74, 1996.

7. Nicoll, D.A., Quednau, B.D., Qui, Z., Xia, Y-R., Lusis, A.J. and Philipson, K.D. Cloning of a third mammalian Na⁺-Ca²⁺ exchanger, NCX3. J. Biol. Chem. 271:24914-24912, 1996.

8. Levitsky, D.O., Fraysse, B., Leoty, C. Nicoll, D.A. and Philipson, K.D. Cooperative interaction between Ca²⁺ binding sites in the hydrophylic loop of the Na⁺-Ca²⁺ exchanger. Mol. Cell. Biochem. 160/161:27-32, 1996.

9. Quednau, B.D., Nicoll, D.A. and Philipson, K.D. Tissue-specific expression and alternative splicing of the Na⁺-Ca²⁺ exchanger isoforms NCX1, NCX2, and NCX3. Am. J. Physiol. 272:C1250-C1261, 1997.

10. Adachi-Akahane, S., Lu, L., Li, Z., Frank, J.S., Philipson, K.D. and Morad, M. Calcium signaling in transgenic mice overexpressing cardiac Na⁺-Ca²⁺ exchanger. J. Gen. Physiol. 109:717-729, 1997.

11. Matsuoka, S., Nicoll, D.A., He, Z. and Philipson, K.D. Regulation of the cardiac Na⁺-Ca²⁺ exchanger by the endogenous XIP region. J. Gen. Physiol. 109:273-286, 1997.

12. He, Z., Voges, K-P., Roben, W., Petesch, N. and Philipson, K.D. Identification of important amino acid residues of the exchanger inhibitory peptide, XIP. J. Memb. Biol. 156:149-156, 1997.

13. Nicholas, S.B., Yang, W., Lee, S.-L., Zhu, H., Philipson, K.D. and Lytton, J. Alternative promoters and cardiac muscle cell-specific expression of the Na⁺-Ca²⁺ exchanger gene (NCX1). Am. J. Physiol. 274:H217-H232, 1998.

14. Doering, A.E., Nicoll, D.A., Lu, Y., Lu, L., Weiss, J.N. and Philipson, K.D. Topology of a functionally important region of the cardiac Na⁺/Ca²⁺ exchanger. J. Biol. Chem. 271:13385-13391, 1998.

15. Linck, B., Qiu, Z., He, Z., Tong, Q., Hilgemann, D.W. and Philipson, K.D. Functional comparison of the three isoforms of the Na⁺/Ca²⁺ exchanger (NCX1, NCX2, NCX3). Am. J. Physiol. 274:C415-C423, 1998.

16. Yao, A., Su, Z., Nonaka, A., Zubair, I., Lu, L., Philipson, K.D., Bridge, J.H.B. and Barry, W.H. The effects of overexpression of the Na/Ca exchanger on [Ca²⁺]_i transients in murine ventricular myocytes. Circ. Res. 82:657-665, 1998.

17. He, Z., Tong, Q., Quednau, B.D., Philipson, K.D. and Hilgemann, D.W. Cloning, expression, and characterization of the squid Na⁺-Ca²⁺ exchanger (NCX-SQ1) J. Gen. Physiol. 111:857-873, 1998.

18. Omelchenko, A., Dyck, C., Hnatowich, M., Buchko, J., Nicoll, D.A., Philipson, K.D. and Hryshko, L.V. Functional differences in ionic regulation between alternatively spliced isoforms of the Na⁺-Ca²⁺ exchanger from Drosophila melanogaster. J. Gen. Physiol. 111:691-702, 1998.

19. Bäumer, At.T., Flesch, M., Kilter, H., Philipson, K.D. and Böhm, M. Overexpression of the Na⁺-Ca²⁺-exchanger leads to enhanced inotropic responsiveness to Na⁺-channel agonist without sarcoplasmic reticulum protein changes in transgenic mice. Biochem. Biophys. Res. Comm. 249:786-790, 1998.

20. Terraciano, C.M.N., De Souza, A.I., Philipson, K.D. and MacLeod, K.T. Na⁺/Ca²⁺ exchange and sarcoplasmic reticular Ca²⁺ regulation in ventricular myocytes from transgenic mice overexpressing the Na⁺/Ca²⁺ exchanger. J. Physiol. 512:651-667, 1998.

21. Nicoll, D.A., Ottolia, M., Lu, L., Lu, Y. and Philipson, K.D. A new topological model of the cardiac sarcolemmal Na⁺-Ca²⁺ exchanger. J. Biol. Chem. In press.